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Thursday, August 25, 2011

All about Vaccines


Continued
Vaccines available in Sri Lanka

Vaccine

Disease/s prevent

Type

Age

Details

BCG
Bacillus Calmette-Guérin

Tuberculosis

Live attenuated

At birth








Vaccines given under the National Immunization Programme

Pentavalent (DTP-HepB-Hib)
Diphtheria,
Pertussis,
Tetanus
Hepatitis B
Haemophilus influenza-B

Toxoid
Live attenuated
Toxoid
Killed
Conjugate
2,4,6 m

Triple (DTP)
Diphtheria,
Pertussis,
Tetanus
Toxoid
Live attenuated
Toxoid

18m
Oral Polio vaccine (OPV)

Poliomyelitis
Live attenuated
2,4,6 18 m & 5y


Measles vaccine
Measles
Live attenuated
9 m

Measles and Rubella (MR)
Measles and Rubella
Live attenuated
3 y
Hepatitis A

Hepatitis A

Killed



Other
Inactivated Polio vaccine (IPV)

Poliomyelitis
Killed
2,4,6 18 m & 5y

Rotavirus vaccine

Rotavirus
Live attenuated

Pneumococcal conjugate vaccine
Pneumonia
Conjugate
Before 2 years

Thursday, August 11, 2011

All about Vaccines


In Sri Lanka we have a well established island wide immunization programme to prevent diseases. Government hospitals provide vaccines for free of charge. However there can be lot of question on vaccination and this is to educate you on vaccination.

What is vaccination? Vaccination is a preventive treatment developed for bacterial or viral infections.

Do all infections have vaccines? No, Vaccines are mainly developed for the diseases with high morbidity and mortality rate or to prevent epidemic conditions. Our immune system and medical care can easily cure many other infections.

Do vaccines contain live viruses? Yes, there are several types of vaccines and following are the commonly found:

  • Live attenuated, uses weakened live viruses which cannot produce the disease in a healthy human

  • Inactivated, uses killed viruses or parts of the killed virus
  • Toxoids, uses inactivated toxins produced by the microorganisms examples are tetanus and diphtheria vaccines

How vaccination prevents infections? When live attenuated/toxoids or inactivated viruses in the vaccine enter in to the body our immune system activates and develops antibodies and memory. When an immunized person is exposed to actual infection the immune system easily fights and eliminates the viruses before harming the body.

How vaccines are administrated: Most common ways are subcutaneous, intramuscular and oral administration.

Does every one develop desired immunity after vaccination? No, usually booster doses are given after the first dose to immunize the most of the population.

Do vaccines provide long lasting immunity? Not all, it depends on the vaccine. Period of protection may vary and some vaccines required periodic administration.

Can someone get infected by vaccination? Rarely Yes, since some vaccines use live organisms, rarely a person with inadequate immunity may be infected and have a chance to develop symptoms and complications similar to actual exposure. However vaccines that use inactivated viruses cannot infect the receiver.

Are there any side effects? Yes mild side effects (i.e. swelling near the injected site, low fever, headache, stomach problems etc.)  are common for any vaccine. These do not need special medical treatments other than mild antipyretics (for fever) and subside within few days.
Though it is uncommon some may develop moderate to severe side effects such as high fever, rashes and breathing difficulties in which the medical treatments are required.
In rare cases some people develop hypersensitivity reactions which can be life threatening.

What are hypersensitivity reactions? They are undesirable reaction to the ingredients of the vaccine by the immune system. It should be noted that it is not a fault of the vaccine or the person administrated.

Can hypersensitivity reactions are preventable? Sometimes not, some people develop hypersensitivity reactions for the first time for a particular vaccine. Therefore it may not be predictable. But emergency medical treatments can prevent the complications. 
Hypersensitivity reactions come soon as less than 60 minutes after vaccination and the symptoms can be severe. Immediate administration of the adrenalin and respiratory support can save the patient. Government or private immunization clinics should have these facilities and trained staff.

Unfortunate rubella vaccine incidents occurred in Sri Lanka most likely to be hypersensitivity reactions.

  • It is better to immunize yourself/children at a facility with emergency medical care.
  • It is also important to stay at the place at least 30 minutes before leaving.

Monday, August 8, 2011

Thalassemia in Sri Lanka

Let’s eradicate Thalassemia from Sri Lanka

What is Thalassemia?
Thalassemia is an inherited (pass from parents) disease which leads to produce absent or low amount of normal hemoglobin. This is literally a preventable disease.


About our genes: Our genes are arranged in pairs with one gene received from each parent. There are two types of hereditary diseases.


Autosomal Dominant One defected gene from one parent is enough for the full blown disease.


Autosomal Recessive – Required both genes to be defected to show symptoms. If each parent carries one defected and one normal gene they do not show the symptoms but have 25% chance to have a child with the disease.  


Thalassemia Minor: Have one defected gene from a parent; usually they do not show symptoms expect for mild anemia. However if married another carrier they may produce a child with Thalassemia

Thalassemia Major: Both genes are required to be defected and show severe symptoms.







Problems
For most of the times Thalassemia Minor does not require medical interventions. However Thalassemia Major has lot of complications including the following necessary to be treated for life.
·   Bone deformities in the face
·         Fatigue
·         Growth failure
·         Shortness of breath
·         Short life expectancy ;Average life span is 20 years
·         Iron overload  ·      Organ failure are the health risks

Treatments (for Thalassemia Major)
  • Lifetime monthly blood transfusions which is painful and reduce the quality of life.
  • Drug therapy throughout the life is required to remove excess iron from the system



Other main problem is High health cost. According to some health news Rs 1,600 million is spent every year to treat Thalassemia and it is about 15% of the total health allocation. During the lifetime average of 10 million rupees is spent for one Thalassemic patient.If this is eradicated, that money could be used to save many lives.

Do only blood related couples produce Thalassemic children?: No, although the chance of having a Thalassemic child to a blood related couple is high due to the tendency of both parents being carriers. Non blood related couples could also have Thalassemic children if both of them are carriers.

What should we do?
It is a great responsibility of us to eradicate this unfortunate preventable disease. Couples can test them selves before the marriage and consider the following

  • If both tested negative-No problem at all
  • If one is positive and other is not – still you can marry and have children (but remember to test your children at least before they get married)
  • If both found positive – If possible don’t get married/ if you marry you can consider adopting a child. But if    you really want to have your own children just think twice about the suffering your child has to bear throughout.

What are the tests to identify the carriers?

• Hemoglobin electrophoresis
• Complete Blood Count
• Iron status studies

Helping institutions
National Thalassaemia Center at Teaching hospital Kurunegala provides assistance to Thalassemic patients.
www.nation.lk


Please refer the article
http://www.nation.lk/2010/08/15/newsfe1.htm for additional information.